Browsing by Author "Han, Y"

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    Novel fluorinated 8-hydroxyquinoline based metal Ionophores for exploring the metal hypothesis of alzheimer’s disease
    (American Chemical Society, 2015-08-10) Liang, SH; Southon, AG; Fraser, BH; Krause-Heuer, AM; Zhang, B; Shoup, TM; Lewis, R; Volitakis, I; Han, Y; Greguric, I; Bush, AI; Vasdev, Y
    Zinc, copper, and iron ions are involved in amyloid-beta (Aβ) deposition and stabilization in Alzheimer’s disease (AD). Consequently, metal binding agents that prevent metal-Aβ interaction and lead to the dissolution of Aβ deposits have become well sought therapeutic and diagnostic targets. However, direct intervention between diseases and metal abnormalities has been challenging and is partially attributed to the lack of a suitable agent to determine and modify metal concentration and distribution in vivo. In the search of metal ionophores, we have identified several promising chemical entities by strategic fluorination of 8-hydroxyquinoline drugs, clioquinol, and PBT2. Compounds 15–17 and 28–30 showed exceptional metal ionophore ability (6–40-fold increase of copper uptake and >2-fold increase of zinc uptake) and inhibition of zinc induced Aβ oligomerization (EC50s < ∼5 μM). These compounds are suitable for further development as drug candidates and/or positron emission tomography (PET) biomarkers if radiolabeled with 18F. © 2015 American Chemical Society
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    Optimization of synthesis of the solid solution, Pb(Zr1-xTix)O-3 on a single substrate using a high-throughput modified molecular-beam epitaxy technique.
    (Materials Research Society, 2009-01) Anderson, PS; Guerin, S; Hayden, BE; Han, Y; Pasha, M; Whittle, KR; Reaney, IM
    Synthesis of Pb(Zr1–xTix)O3 (PZT) on a single substrate using a high-throughput molecular-beam epitaxy technique was demonstrated. In situ synthesis of crystalline PZT at elevated substrate temperatures could not be achieved, as reevaporation of Pb (PbO) occurred and the partial pressure of O2 was insufficient to prevent formation of a PbPtx phase during deposition. Instead, ex situ postdeposition annealing was performed on PZT deposited at room temperature. Dense single phase PZT was prepared with a compositional range of 0.1 > x > 0.9, for film thicknesses up to 800 nm. Transmission electron microscopy revealed the grain size increased from 50 nm to ~0.5 µm with increasing Zr-concentration and became more columnar. Raman, x-ray diffraction, and scanning electron microscopy/energy dispersive spectroscopy results revealed a morphotropic phase boundary between rhombohedral and tetragonal phases occurred at x ~0.4 rather than at x = 0.47 in bulk ceramics. This was attributed to clamping arising from mismatch in thermal expansion between the film and substrate. © 2009, Materials Research Society
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    Status of the compactlight design study
    (JACoW Publishing, 2019-05-19) D'Auria, G; Mitri, SD; Rochow, RA; Latina, A; Liu, X; Rossi, C; Schulte, D; Stapnes, S; Wu, X; Castañeda Cortes, HM; Clarke, J; Dunning, DJ; Thompson, N; Fang, W; Gazis, E; Gazis, N; Tanke, E; Trachnas, E; Goryashko, V; Jacewicz, M; Ruber, R; Taylor, G; Dowd, RT; Zhu, D; Aksoy, A; Nergiz, Z; Apsimon, R; Burt, G; Castilla, A; Priem, H; Janssen, X; Luiten, J; Mutsaers, P; Stragier, X; Alesini, D; Bellaveglia, M; Buonomo, B; Cardelli, F; Croia, M; Diomede, M; Ferrario, M; Gallo, A; Giribono, A; Piersanti, L; Scifo, J; Spataro, B; Vaccarezza, C; Geometrante, R; Kokole, M; Arnesano, J; Bosco, F; Ficcadenti, L; Mostacci, A; Palumbo, L; Dattoli, G; Nguyen, F; Petralia, A; Marcos, J; Marín, E; Muñoz Horta, R; Perez, F; Faus-Golfe, A; Han, Y; Bernhard, A; Gethmann, J; Calvi, M; Schmidt, T; Zhang, K; Esperante, D; Fuster, J; Gimeno, B; Gonzalez-Iglesias, D; Aicheler, M; Hoekstra, R; Cross, AW; Nix, L; Zhang, L
    CompactLight (XLS) is an International Collaboration of 24 partners and 5 third parties, funded by the European Union through the Horizon 2020 Research and Innovation Programme. The main goal of the project, which started in January 2018 with a duration of 36 months, is the design of an hard X-ray FEL facility beyond today’s state of the art, using the latest concepts for bright electron photo-injectors, high-gradient accelerating structures, and innovative shortperiod undulators. The specifications of the facility and the parameters of the future FEL are driven by the demands of potential users and the associated science cases. In this paper we will give an overview on the ongoing activities and the major results achieved until now. © The Authors - CC-BY 3.0 licence