Browsing by Author "Hall, MD"

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    Stabilization of triam(m)inechloridoplatinum complexes by oxidation to PtIV.
    (CSIRO Publishing, 2011-03-11) Daly, HL; Hall, MD; Failes, TW; Zhang, M; Foran, GJ; Hambley, TW
    PtIV analogues of the active end groups {PtClN3} of multinuclear Pt anticancer drugs have been investigated. The crystal structure of trans,mer-[PtCl(OH)2(dien)]Cl shows that the bond lengths are similar to those in the dihydroxidoplatinum(iv) analogue of cisplatin. The axial ligands are shown to be the predominant influence on reduction potentials with the dihydroxido complex trans,mer-[PtCl(OH)2(NH3)3]Cl being the most resistant to reduction. X-ray absorption near-edge spectroscopy is shown to be suitable for monitoring the oxidation state of these complexes and reveals that trans,mer-[PtCl(OH)2(NH3)3]+ survives for more than 2 h in cancer cells. © 2011, CSIRO Publishing
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    Using XANES to monitor the oxidation state of cobalt complexes
    (CSIRO Publishing, 2007-02-14) Hall, MD; Underwood, CK; Failes, TW; Foran, GJ; Hambley, TW
    X-Ray absorption near-edge structure (XANES) spectroscopy was used to monitor the oxidation state of cobalt following treatment of Co-III complexes with reducing agents such as ascorbate and cysteine. It was established that the XANES spectra of mixtures of Co-II and Co-III complexes can be used to calculate proportions of the two oxidation states by monitoring the height of the Co K-edge. The relationships developed were used to estimate proportions of each complex in solutions of Co-III complexes treated with reducing agents. © 2007, CSIRO Publishing