Browsing by Author "Fahey, F"

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    Imaging cancer using PET - the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody.
    (Elsevier, 2011-01-01) Dearling, JLJ; Voss, SD; Dunning, P; Snay, E; Fahey, F; Smith, SV; Huston, JS; Meares, CF; Treves, ST; Packard, AB
    Use of copper radioisotopes in antibody radiolabeling is challenged by reported loss of the radionuclide from the bifunctional chelator used to label the protein. The objective of this study was to investigate the relationship between the thermodynamic stability of the 64Cu-complexes of five commonly used bifunctional chelators (BFCs) and the biodistribution of an antibody labeled with 64Cu using these chelators in tumor-bearing mice. © 2011, Elsevier