Browsing by Author "Druce, MJ"

Now showing 1 - 4 of 4
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    An analysis of molybdenum-99 expiry times in sodium pertechnetate derived from a dry-bed generator
    (Australian Nuclear Science and Technology Organisation, 2000-03) Barnes, RK; Anderson, PJ; Stimson, D; Chapman, J; Druce, MJ
    Fission-based 99 Mo/ 99m Tc generators have undergone evolutionary changes since they were first manufactured at the Lucas Heights Laboratories in the late 1960s for the Australian nuclear medicine community. This study is aimed at understanding the chemistries which influence the behaviour of the heterogeneous molybdenum-alumina system in a chromatographic generator. The quality of sodium pertechnetate derived from a dry-bed generator is enhanced when compared with the traditional wet-bed technologies. Data is presented which compare the extent of 99Mo desorption from both wet and dry-bed chromatographic generators. The expiration times for sodium pertechnetate based on 99Mo breakthrough are significantly greater for the recently developed dry-bed generators.
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    ANSTO Nuclear Medicine—towards a stable supply of Mo- 99
    (American Nuclear Society, 2014-08-25) Druce, MJ; Moore, MJE
    Not available.
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    The derivation of a specification for fission-produced molybdenum-99 for the preparation of AAEC (autoclaved) MK II B 99Mo/99m Tc generators.
    (Australian Atomic Energy Commission, 1987-01) Boyd, RE; Druce, MJ
    Technetium-99m eluates are shown to contain significantly lower levels of radionuclidic impurities than the parent 99 Mo feed solution. It is well established that alumina absorption of 99 Mo followed by saline elution of 99m Tc leads to a considerable overall decontamination effect. This decontamination factor (DF) is defined as the ratio of radionuclidic impurities in the 99 Mo feed solution to radionuclidic impurities in the eluted 99m Tc. Impurity measurements were made on samples of fission product 99m Mo feed solutions and 99m Tc eluates from nominal 20 GBq and 150 GBq AAEC (autoclaved) Mk IIB generators. Minimum DFs were obtained which were then used to derive radionuclidic purity criteria for 99 Mo to satisfy the requirements of the British Pharmacopoeia.
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    Six problems with the 6-day Curie and a solution
    (Springer Nature, 2015-03-17) Paterson, AW; Druce, MJ; Killen, E
    In this review the major shortfalls of the unit of sale for the Mo-99 supply chain—the 6-day Curie—are identified and discussed. These include its status as an inconsistent, out-dated, non-SI unit, and its use causing propagation of inefficient logistics within the Mo-99 supply chain. An alternative Mo-99 unit of sale is proposed: Becquerels time-stamped at the Port of Despatch. Adoption of the new unit is proposed as a catalyst in the move away from the current economically unsustainable, Mo-99 supply chain in favour of simplicity, self-regulation, transparency, efficiency, and full-cost recovery in line with High-Level Group for the Security of Supply of Medical Radioisotopes recommendations. © 2020 Springer Nature Switzerland AG