Browsing by Author "De Leonardis, F"

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    Purification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction
    (Elsevier B.V., 2013-03-08) Tarn, MD; Pascali, G; De Leonardis, F; Watts, P; Salvadori, PA; Pamme, N
    Microfluidic devices have shown great potential for the production of positron emission tomography (PET) radiotracers, but most devices have focused only on the synthesis step of the procedure, typically neglecting the other important steps such as [18F]fluoride pre-concentration and radiotracer purification that could equally benefit from miniaturisation. Here, we demonstrate the development of microfluidic modules for the purification of PET radiotracers, particularly 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG), via the use of on-chip solid-phase extraction (SPE). In these initial tests, the SPE modules were able to yield [18F]FDG with up to 90% radiochemical purity, and methods are proposed for further increasing this value. © 2013 Elsevier B.V.
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    Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals
    (The Royal Society of Chemistry, 2013-03-25) Arima, V; Pascali, G; Lade, O; Kretschmer, HR; Bernsdorf, I; Hammond, V; Watts, P; De Leonardis, F; Tarn, MD; Pamme, N; Cvetkovic, BJ; Ditrrich, PS; Vasovic, N; Duane, R; Jaksic, A; Zacheo, A; Zizzari, A; Marra, L; Perrone, E; Salvadori, PA; Rinaldi, R
    AbstractWe have developed an integrated microfluidic platform for producing 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40–80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals. © 2013 The Royal Society of Chemistry