Browsing by Author "Black, DS"

Now showing 1 - 4 of 4
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    Efficient access to chromeno[4,3-b]quinolines related to dependensin
    (© Georg Thieme Verlag Stuttgart, 2017-08-08) Dobrowolski, JC; Fraser, BH; Bhadbhade, MM; Black, DS; Kumar, N
    We report a robust synthesis of novel chromeno[4,3-b]quinoline derivatives structurally similar to the natural product dependensin. The target compounds are accessed through the acid-catalysed condensation of 2-aminoacetophenones or 2-aminochalcones with substituted flavanones, which are in turn obtained from 2-hydroxyacetophenones and benzaldehydes. © 2017 Georg Thieme Verlag Stuttgart
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    A general and efficient synthesis of 5,6-dihydrodibenzo[b,h][1,6]naphthyridine derivatives
    (Elsevier B. V., 2016-12-07) Dobrowolski, JC; Katen, A; Fraser, BH; Bhadbhade, MM; Black, DS; Kumar, N
    A two-step procedure for the synthesis of dihydrodibenzonaphthyridine derivatives from benzaldehydes and 2-aminoacetophenones, proceeding through a substituted dihydroquinolone intermediate, is described. The synthetic protocol allows for a versatile and robust coupling method between a range of 2-aminoacetophenones or 2-aminobenzophenones and a selection of substituted dihydroquinolones. © 2016 Elsevier B.V.
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    A general synthesis of 7-Phenyl-7,13-dihydro-8H-benzo[6,7]azepino[3,2-c]quinolin-8-ones
    (Thieme, 2019-02-13) Dobrowolski, JC; Nguyen, DHT; Fraser, BH; Bhadbhade, MM; Black, DS; Kumar, N
    Complex benzazepinoquinolone scaffolds can be accessed from the reaction of 2-aminoacetophenones and oxindole derivatives and feature the seven-membered azepine ring moiety commonly found in a range of drug molecules. The described reaction is generally applicable and allows for rapid access to a diverse range of new structures with further potential to build more elaborate molecules. © 2021 Georg Thieme Verlag KG
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    A general synthesis of benzoazepinoindoles – a new class of heterocycles
    (Thieme, 2019-10-09) Dobrowolski, JC; Nguyen, DHT; Fraser, BH; Bhadbhade, MM; Black, DS; Kumar, N
    A new class of heterocyclic compounds, namely the benzoazepinoindolones, has been synthesised through a base-catalysed cyclisation reaction of 1,4-bis(2-aminophenyl)-2-phenylbutane-1,4-dione derivatives and features the prominent seven-membered azepine ring moiety. This synthesis has considerable scope for the rapid generation of more complex structures and is inexpensive and generally applicable. © 2019 Georg Thieme Verlag