Browsing by Author "Arima, V"

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    Microfluidics in Planar Microchannels: Synthesis of Chemical Compounds On-Chip.
    (Springer Link, 2014-10-14) Arima, V; Watts, P; Pascali, G
    Microreactors are a wide class of devices that are currently playing a prominent role in several research fields such as biology, medicine, food chemistry, environmental analysis, up to the production of compounds in organic chemistry. Several typologies of microreactors have been produced with tubular or planar shapes, of different materials and designs. In this chapter, an overview of planar microchannel-based microreactors and their application to organic chemistry is given. Initially, after recalling the main theoretical parameters of microfluidics, an introduction of the proposed technology and the main requirements to perform mixing, which is essential to perform chemical synthesis on-chip, is presented. Silicon and glass microreactors, the most common planar systems for organic chemistry, are described with the aim of pointing out the most important parameters to be taken into consideration in the planning of a specific microreactor to be used for mixing, purification or crystallization of chemicals at the microscale. Then, several applications of initially described microreactors to organic chemistry for research applications are given. In the next section, the use of planar microchannel microreactors in the field of radiochemistry is reported. The radiopharmaceutical application is not casual, being a sector in which the microreactor technology is very promising, due to the need of quickly producing small and fresh amounts of products in a controlled environment. Finally, for completeness, other approaches beyond planar microchannels are mentioned: mesoreactors towards industrial level synthesis and micro-vessels for radiochemistry. © Springer International Publishing Switzerland 2015
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    Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals
    (The Royal Society of Chemistry, 2013-03-25) Arima, V; Pascali, G; Lade, O; Kretschmer, HR; Bernsdorf, I; Hammond, V; Watts, P; De Leonardis, F; Tarn, MD; Pamme, N; Cvetkovic, BJ; Ditrrich, PS; Vasovic, N; Duane, R; Jaksic, A; Zacheo, A; Zizzari, A; Marra, L; Perrone, E; Salvadori, PA; Rinaldi, R
    AbstractWe have developed an integrated microfluidic platform for producing 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40–80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals. © 2013 The Royal Society of Chemistry