Radiochemical separation and quality assessment for the 68Zn target based 64Cu radioisotope production
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Date
2008-08-01
Journal Title
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Publisher
Springer
Abstract
The radiochemical separation of the different radionuclides (64Cu, 67Cu, 67Ga, 66Ga, 56Ni, 57Ni, 55Co, 56Co, 57Co, 65Zn, 196Au ) induced in the Ni
supported Cu substrate – 68Zn target system, which was bombarded with the 29.0 MeV proton beam, was performed by ion-exchange
chromatography using successive isocratic and/or concentration gradient elution techniques. The overlapped gamma-ray spectrum analysis method
was developed to assess the 67Ga and 67Cu content in the 64Cu product and even in the post-67Ga production 68Zn target solution without the
support of radiochemical separation. This method was used for the assessment of 64+67Cu radioisotope separation from 67Ga , the quality control of
64Cu product and the determination of the 68Zn (p,2p)67Cu reaction yield. The improvement in the targetry and the optimization of proton beam
energy for the 68Zn target based 64Cu and 67Ga production were proposed based on the stopping power and range of the incident proton and on the excitation functions, reaction yields and different radionuclides induced in the target system. © 2008, Springer.
Description
Keywords
Zinc 68, Copper 64, Radioisotopes, Cyclotrons, Ion exchange chromatography, Proton beams
Citation
Le, V.S., Pellegrini, P., Katsifis A., Howse J., & Greguric I., (2008). Radiochemical separation and quality assessment for the 68Zn target based 64Cu radioisotope production. Journal of Radioanalytical and Nuclear Chemistry, 277(2), 451–466. doi:10.1007/s10967-007-7143-x